Evaluation of whole genome amplification and bioinformatic methods for the characterization of Leishmania genomes at a single cell level
H. Imamura, M. Jara, P. Monsieurs, M. Sanders, I. Maes, M. Vanaerschot, M. Berriman, J. A. Cotton, J.-C. Dujardin, M. A. Domagalska
The paper evaluates WGA methods for Leishmania single-cell genomics, finding PicoPlex better for aneuploidy and RepliG for SNPs, and detects aneuploidy mosaicism in L. braziliensis.
bioRxiv · Feb 20, 2020Microbiology