Author

J.-C. Dujardin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Assay:whole-genome sequencing· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2

Frequent Co-Authors

M. A. Domagalska· 6 shared I. Maes· 5 shared H. Imamura· 4 shared M. Jara· 4 shared M. Sanders· 4 shared F. Van den Broeck· 3 shared J. A. Cotton· 3 shared J. Arevalo· 3 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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6 shared papersMicrobiology

M. A. Domagalska

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Author profile →

7 papers

Recent·Most cited

Source tracing of Leishmania donovani in emerging foci of visceral leishmaniasis in West Nepal

P. Monsieurs, K. Cloots, S. Uranw, M. R. Banjara, P. Ghimire, S. Burza, E. Hasker, J.-C. Dujardin, M. A. Domagalska

The paper sequences Leishmania donovani genomes from visceral leishmaniasis cases in West Nepal, identifying new and rare lineages not previously seen in the region.

bioRxiv · Aug 22, 2023 · PreprintMicrobiology

Unveiling drug tolerant and persister-like cells in Leishmania braziliensis lines derived from patients with cutaneous leishmaniasis

M. Jara, J. Arevalo, A. Llanos-Cuentas, F. Van den Broeck, M. A. Domagalska, J.-C. Dujardin

The paper demonstrates drug tolerance in Leishmania braziliensis strains through in vitro models, showing quiescence and reversibility without genetic resistance.

bioRxiv · Jul 4, 2023 · PreprintMicrobiology

Parasite hybridization promotes spreading of endosymbiotic viruses

S. Heeren, I. Maes, M. Sanders, L.-F. Lye, J. Arevalo, A. Llanos Cuentas, L. Garcia, P. Lemey, S. M. Beverley, J. Cotton, J.-C. Dujardin, F. Van den Broeck

This study shows that parasite hybridization in cutaneous leishmaniasis increases the spread of endosymbiotic viruses, contributing to disease severity.

bioRxiv · Mar 24, 2023Evolutionary Biology

Genomic and phenotypic characterization of experimentally selected resistant Leishmania donovani reveals a role for dynamin-1 like protein in the mechanism of resistance to a novel anti-leishmanial compound

A. Hefnawy, G. Negreira, M. Jara, J. A. Cotton, I. Maes, E. D'Haenens, H. Imamura, B. Cuypers, P. Monsieurs, C. Mouchtoglou, H. De Winter, M. Berriman, M. Sanders, J. Martin, G. De Muylder, , M. A. Domagalska

This study experimentally selects resistance to a novel anti-leishmanial compound in Leishmania donovani and identifies mutations in the dynamin-1-like protein as a key mechanism of resistance.

bioRxiv · Jan 5, 2021Microbiology

Evaluation of whole genome amplification and bioinformatic methods for the characterization of Leishmania genomes at a single cell level

H. Imamura, M. Jara, P. Monsieurs, M. Sanders, I. Maes, M. Vanaerschot, M. Berriman, J. A. Cotton, J.-C. Dujardin, M. A. Domagalska

The paper evaluates WGA methods for Leishmania single-cell genomics, finding PicoPlex better for aneuploidy and RepliG for SNPs, and detects aneuploidy mosaicism in L. braziliensis.

bioRxiv · Feb 20, 2020Microbiology

Tracking of quiescence in Leishmania by quantifying the expression of GFP in the ribosomal DNA locus

M. Jara, I. Maes, H. Imamura, M. A. Domagalska, J.-C. Dujardin, J. Arevalo

The paper develops a biosensor to track quiescence in Leishmania by quantifying GFP expression from the ribosomal DNA locus, showing it correlates with replication state and is reversible.

Scientific Reports · Dec 12, 2019Peer-reviewedMicrobiology

Genomes of intracellular Leishmania parasites directly sequenced from patients

M. A. Domagalska, H. Imamura, M. Sanders, F. Van den Broeck, N. R. Bhattarai, M. Vanaerschot, I. Maes, E. D'Haenens, K. Rai, S. Rijal, M. Berriman, J. A. Cotton, J.-C. Dujardin

This paper develops a method to directly sequence Leishmania genomes from clinical samples, revealing genomic differences between intracellular parasites and cultured isolates.

bioRxiv · Sep 26, 2019Microbiology