Author

M. W. Becker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

B. J. Frisch· 2 shared E. A. Phelps· 2 shared J. L. Liesveld· 2 shared J. M. Ashton· 2 shared L. M. Calvi· 2 shared A. Khan· 1 shared A. Powell· 1 shared A. Sharipol· 1 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersPathology

B. J. Frisch

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Temporal Single Cell Analysis of Leukemia Microenvironment Identifies Taurine-Taurine Transporter Axis as a Key Regulator of Myeloid Leukemia

B. J. Rodems, S. Sharma, C. D. Baker, C. M. Kaszuba, T. Ito, J. L. Liesveld, L. M. Calvi, M. W. Becker, C. T. Jordan, J. M. Ashton, J. Bajaj

This study identifies the taurine-taurine transporter axis as a critical regulator of myeloid leukemia using temporal single-cell RNA-sequencing and functional experiments.

bioRxiv · May 11, 2024 · PreprintCancer Biology

Elevated Lactate in the AML Bone Marrow Microenvironment Polarizes Leukemia-Associated Macrophages via GPR81 Signaling

C. A. Soto, M. L. Lesch, J. L. Becker, A. Sharipol, A. Khan, X. L. Shafer, M. W. Becker, J. C. Munger, B. J. Frisch

This study identifies lactate as a key factor in AML-induced immunosuppression by polarizing leukemia-associated macrophages via GPR81 signaling.

bioRxiv · Nov 13, 2023 · PreprintPathology

Serum from pregnant donors induces human beta cell proliferation and insulin secretion

K. R. Sylvester-Armstrong, C. F. Reeder, A. Powell, M. W. Becker, D. W. Hagan, J. Chen, C. E. Mathews, C. H. Wasserfall, M. A. Atkinson, R. Egerman, E. A. Phelps

This study shows that serum from pregnant donors can stimulate human beta cell proliferation and insulin secretion, suggesting potential for beta cell expansion.

bioRxiv · Apr 17, 2023 · PreprintCell Biology

Myelodysplastic syndromes disable human CD271+VCAM1+CD146+ niches supporting normal hematopoietic stem/progenitor cells

Y. kawano, H. Kawano, D. Ghoneim, T. J. Fountaine, D. K. Byun, M. W. LaMere, J. H. Mendler, T.-C. Ho, N. A. Salama, J. R. Myers, S. E. Hussein, B. J. Frisch, J. M. Ashton, M. Azadniv, J. L. Liesveld, , L. M. Calvi

The paper identifies a specific MSC subset supporting normal HSPCs and shows its dysfunction in MDS.

bioRxiv · Apr 9, 2023 · PreprintCancer Biology

Immune engineered extracellular vesicles to modulate T cell activation in the context of type 1 diabetes

M. W. Becker, L. D. Peters, T. Myint, T. M. Brusko, E. A. Phelps

This study generates engineered extracellular vesicles to modulate T cell activation in type 1 diabetes by presenting HLA-A2 and costimulatory molecules, showing they can activate or suppress CD8+ T cells depending on PD-L1 presence.

bioRxiv · Nov 23, 2022Bioengineering