Immune engineered extracellular vesicles to modulate T cell activation in the context of type 1 diabetes
M. W. Becker, L. D. Peters, T. Myint, T. M. Brusko, E. A. Phelps
This study generates engineered extracellular vesicles to modulate T cell activation in type 1 diabetes by presenting HLA-A2 and costimulatory molecules, showing they can activate or suppress CD8+ T cells depending on PD-L1 presence.
bioRxiv · Nov 23, 2022Bioengineering