M. Wierer

Reprogramming neuroblastoma by diet-enhanced polyamine depletion

This paper shows that combining dietary restriction of arginine and proline with polyamine depletion drugs enhances tumor differentiation and survival in a neuroblastoma mouse model by disrupting oncogenic translation.

Human skeletal muscle fiber heterogeneity beyond myosin heavy chains

This study identifies sources of skeletal muscle fiber heterogeneity beyond myosin heavy chains using transcriptomic and proteomic data from human muscle fibers.

Comprehensive chromatin proteomics resolves functional phases of pluripotency

The paper develops a proteomic method to analyze chromatome dynamics during pluripotency phases, revealing regulatory complex binding and rearrangements.

Defining the RBPome of T helper cells to study higher order post-transcriptional gene regulation

The paper identifies the core RNA-binding protein (RBP)ome in human and mouse T helper cells, revealing new regulators of post-transcriptional gene regulation, including Celf1 as a Roquin-1-dependent coregulator of Icos.