Author

R. A. Seaborne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Physiology· 5 Cell Biology· 1

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Organism:human· 5 Assay:DNA methylation· 4 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:proteomics· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2

Frequent Co-Authors

A. P. Sharples· 5 shared D. C. Turner· 5 shared D. J. Owens· 3 shared P. P. Gorski· 3 shared A. K. Larin· 2 shared B. Drust· 2 shared C. E. Stewart· 2 shared D. C. Hughes· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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5 shared papersPhysiology

A. P. Sharples

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Author profile →

6 papers

Recent·Most cited

Human skeletal muscle fiber heterogeneity beyond myosin heavy chains

R. Moreno-Justicia, T. Van der Stede, B. Stocks, J. Laitila, R. A. Seaborne, A. Van de Loock, E. Lievens, D. Samodova, L. Marin-Arraiza, O. Dmytriyeva, R. Browaeys, K. Van Vossel, L. Moesgaard, N. Yigit, J. Anckaert, , A. S. Deshmukh

This study identifies sources of skeletal muscle fiber heterogeneity beyond myosin heavy chains using transcriptomic and proteomic data from human muscle fibers.

bioRxiv · Sep 7, 2023Physiology

The methylome and comparative transcriptome after high intensity sprint exercise in human skeletal muscle

M. F. Maasar, D. C. Turner, P. P. Gorski, R. A. Seaborne, J. A. Strauss, S. O. Shepherd, M. Cocks, N. J. Pillon, J. R. Zierath, A. T. Hulton, B. Drust, A. P. Sharples

This study examines the methylome and transcriptome changes in human skeletal muscle after high-intensity sprint exercise, finding that change of direction exercise causes greater epigenetic and gene expression changes than straight line sprinting.

bioRxiv · Sep 11, 2020 · PreprintPhysiology

Knockdown of the E3 Ubiquitin ligase UBR5 and its role in skeletal muscle anabolism

D. C. Turner, D. C. Hughes, L. M. Baehr, R. A. Seaborne, M. Viggars, J. C. Jarvis, P. P. Gorski, C. E. Stewart, D. J. Owens, S. C. Bodine, A. P. Sharples

This study shows that knocking down UBR5 leads to skeletal muscle atrophy by disrupting anabolic signaling pathways.

bioRxiv · Jun 5, 2020Cell Biology

DNA methylation across the genome in aged human skeletal muscle tissue and stem cells: The role of HOX genes and physical activity

D. C. Turner, P. P. Gorski, M. F. Maasar, R. A. Seaborne, P. Baumert, A. D. Brown, M. O. Kitchen, R. M. Erskine, I. Dos-Remedios, S. Voisin, N. Eynon, R. I. Sultanov, O. V. Borisov, A. K. Larin, E. A. Semenova, , A. P. Sharples

This study identifies age-related hypermethylation in HOX genes in aged human skeletal muscle and stem cells, with physical activity inversely affecting methylation in some genes.

bioRxiv · Dec 27, 2019Physiology

UBR5 is a Novel E3 Ubiquitin Ligase involved in Skeletal Muscle Hypertrophy and Recovery from Atrophy

R. A. Seaborne, D. C. Hughes, D. C. Turner, D. J. Owens, L. M. Baehr, P. Gorski, E. A. Semenova, O. V. Borisov, A. K. Larin, D. V. Popov, E. V. Generozov, H. Sutherland, I. I. Ahmetov, J. C. Jarvis, S. C. Bodine, A. P. Sharples

This paper identifies UBR5 as a novel E3 ubiquitin ligase inversely regulated to MuRF1/MAFbx, epigenetically modulated during skeletal muscle recovery from atrophy and hypertrophy, and genetically associated with muscle fiber size and strength traits.

bioRxiv · Apr 29, 2019Physiology

Comparative Transcriptome and Methylome Analysis in Human Skeletal Muscle Anabolism, Hypertrophy and Epigenetic Memory.

D. C. Turner, R. A. Seaborne, A. P. Sharples

This study identifies differentially methylated genes associated with human skeletal muscle anabolism, hypertrophy, and epigenetic memory by comparing transcriptome and methylome data from acute and chronic resistance exercise.

bioRxiv · Feb 15, 2019Physiology