M. Yukawa

An atlas of gene regulatory networks for memory CD4+ T cells in youth and old age

The paper constructs an atlas of gene regulatory networks for memory CD4+ T cells in young and old mice, revealing age-related changes in transcription factor control and cell-cell communication.

Escape from mitotic catastrophe by actin-dependent nuclear displacement in fission yeast

This study shows that fission yeast uses actin-dependent nuclear displacement during mitosis to avoid a lethal cell division defect.

Two XMAP215/TOG microtubule polymerases, Alp14 and Dis1, play non-exchangeable, distinct roles in microtubule organisation in fission yeast

This study investigates the distinct functional roles of Alp14 and Dis1, two XMAP215/TOG microtubule polymerases, in fission yeast spindle organization and mitotic progression.

Co-Stimulation-Induced AP-1 Activity is Required for Chromatin Opening During T Cell Activation

This study shows AP-1 activity is essential for chromatin opening during T cell activation and links AP-1 to immune disease risk loci.

Kinesin-6 Klp9 plays motor-dependent and -independent roles in collaboration with Kinesin-5 Cut7 and the microtubule crosslinker Ase1 in fission yeast

This study identifies dual roles of Klp9 in fission yeast mitosis, showing it contributes to force generation with Cut7 and structural integrity with Ase1 during anaphase B.

Fission yeast cells overproducing HSET/KIFC1 provides a useful tool for identification and evaluation of human kinesin-14 inhibitors

This paper evaluates HSET inhibitors in fission yeast to identify selective kinesin-14 inhibitors and assess their off-target effects.

Two spatially distinct Kinesin-14 Pkl1 and Klp2 generate collaborative inward forces against Kinesin-5 Cut7 in S. pombe

This study shows how two Kinesin-14 proteins in fission yeast generate inward forces against Kinesin-5 by localizing to different structures, maintaining spindle bipolarity.