Y. Yamada

Sildenafil amplifies calcium influx and insulin secretion in pancreatic β cells

This study shows sildenafil enhances insulin secretion in pancreatic β cells by increasing calcium influx, independent of L-type Ca2+ channels and PDE5.

Heart generation via blastocyst complementation in Mesp1/2-deficient mice

This study generates functional adult hearts in Mesp1/2-deficient mice using blastocyst complementation with pluripotent stem cells, showing successful derivation of all cardiovascular lineages from exogenous cells.

Neonicotinoids and Varroa mites force the extending of longevity in a bee colony during overwintering to forget

The paper uses a mathematical model to show that neonicotinoids and Varroa mites disrupt the seasonal extension of bee colony longevity during overwintering.

NMR analysis of the homodimeric structure of a D-Ala-D-Ala metallopeptidase, VanX, from vancomycin-resistant bacteria

The paper determines the dimeric structure of VanX using NMR and identifies a monomeric form for inhibitor screening.

Theoretical investigation of active listening behavior based on the echolocation of CF-FM bats

This paper develops a mathematical model to investigate how bat ear motions contribute to 3D direction detection during echolocation, finding that specific ear movements enhance accuracy and robustness.

Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats

This study shows naked mole-rats (NMRs) resist chemical carcinogenesis through reduced inflammatory responses linked to necroptosis deficiency.

Tandem mass spectrum similarity-based network analysis using 13C-labeled and non-labeled metabolome data to identify the biosynthesis pathway of the blood pressure-lowering asparagus metabolite asparaptine A

The paper identifies the biosynthesis pathway of asparaptine A using metabolome network analysis and shows its blood pressure-lowering effects in mice.

Multi-metabolomics using imaging mass spectrometry and liquid chromatography-tandem mass spectrometry for spatially characterizing monoterpene indole alkaloids secreted from roots

The paper uses imaging mass spectrometry and LC-MS/MS to spatially characterize monoterpene indole alkaloids released from plant roots in agar.

Cryo-EM structure of the MgtE Mg2+ channel pore domain in Mg2+-free conditions reveals cytoplasmic pore opening

The paper determines the cryo-EM structure of MgtE in Mg2+-free conditions, revealing cytoplasmic pore opening and kink motions in TM2 and TM5 helices.

Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

This study generates human hepatic progenitor cells from primary hepatocytes that can repopulate injured livers and redifferentiate into functional hepatocytes.

Relationship between ocean area and incidence of anthropogenic debris ingested by longnose lancetfish (Alepisaurus ferox)

This study examines plastic ingestion in longnose lancetfish across different ocean areas, finding higher incidence in Sagami Bay compared to the North Pacific and Indian Ocean.

Development of oocytes in a post-spawning Japanese eel Anguilla japonica Temminck & Schlegel in captivity

The paper reports the observation of developing oocytes in a post-spawning Japanese eel in captivity, suggesting possible multiple spawning potential.

Adenosine Deaminase Acting on RNA 1 Associates with Orf Virus OV20.0 and Enhances Viral Replication

This study identifies a novel interaction between ORFV protein OV20.0 and ADAR1, showing OV20.0 suppresses ADAR1's A-to-I editing and enhances viral replication by inhibiting PKR phosphorylation.

Two spatially distinct Kinesin-14 Pkl1 and Klp2 generate collaborative inward forces against Kinesin-5 Cut7 in S. pombe

This study shows how two Kinesin-14 proteins in fission yeast generate inward forces against Kinesin-5 by localizing to different structures, maintaining spindle bipolarity.

Sequential interactions with Mre11-Rad50-Nbs1 activate ATM/Tel1 at DNA double-strand breaks and telomeres

This study shows that Tel1 activation at DNA breaks and telomeres occurs through sequential interactions with the MRN complex, requiring Nbs1 for high-affinity binding and Mre11-Rad50 for low-affinity activation.