Establishing cell-intrinsic limitations in cell cycle progression controls graft growth and promotes differentiation of pancreatic endocrine cells
L. Sui, D. M. Egli, Y. Xin, D. C. Georgieva, G. Diedenhofen, L. Haataja, Q. Su, Y. Wang, M. Zuccaro, J. Kim, J. Fu, Y. Xing, D. Baum, P. Arvan, F. Barbetti, , R. Goland
The paper investigates how limitations in S-phase progression affect pancreatic endocrine differentiation and graft growth, finding that impaired DNA replication enhances differentiation and prevents cystic growth.
bioRxiv · Mar 13, 2020Cell Biology