Author

M. Jasin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:development & morphogenesis· 2 Approach:comparative / phylogenetic analysis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

T. White· 2 shared A. Allouch· 1 shared A. Bradley· 1 shared A. Carver· 1 shared A. De Cian· 1 shared A. Maldonado-Linares· 1 shared A. Martinez-Marchal· 1 shared A. P. Makohon-Moore· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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2 shared papersBiochemistry

T. White

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin

A. Carver, T.-Y. Yu, L. Yates, T. White, R. Wang, K. Lister, M. Jasin, X. Zhang

This study identifies the molecular mechanism by which FIGNL1 disassembles RAD51 filaments from DNA and chromatin, revealing its role in genome stability.

bioRxiv · Jul 16, 2024Biochemistry

In vivo inactivation of RAD51-mediated homologous recombination leads to premature aging, but not to tumorigenesis

G. Matos-Rodrigues, V. Barroca, A.-A. Muhammad, A. Allouch, S. Koundrioukoff, D. Lewandowski, E. Despras, J. Guirouilh-Barbat, L. Frappart, P. Kannouche, P. Dupaigne, E. Le Cam, J.-L. Perfettini, P.-H. Romeo, M. Debatisse, , B. S. Lopez

This study shows that inactivating RAD51 in mice causes premature aging but not cancer, suggesting RAD51 is critical for progenitor cell homeostasis.

bioRxiv · Jan 17, 2022 · PreprintCancer Biology

Selection for Decreased BRCA2 Functional Activity in Homo sapiens After Divergence from the Chimpanzee-Human Last Common Ancestor

C. A. Iacobuzio-Donahue, J. Huang, Y. Zhong, A. P. Makohon-Moore, T. White, M. Jasin, M. A. Norell, W. C. Wheeler

The paper identifies a human-specific BRCA2 variant that reduces DNA repair ability, suggesting positive selection for decreased BRCA2 function in human evolution.

bioRxiv · Nov 16, 2020 · PreprintEvolutionary Biology

Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells

E. B. Garcin, S. Gon, R. Prakash, M. R. Sullivan, G. J. Brunette, A. De Cian, J.-P. Concordet, C. Giovannangeli, W. G. Dirks, S. Eberth, K. A. Bernstein, M. Jasin, M. Modesti

This study investigates the roles of RAD51 paralogs in DNA repair across different human cell types, finding essential differences in their functions and identifying potential implications for cancer therapy.

bioRxiv · Apr 15, 2019Cell Biology

Inter-homologue repair in fertilized human eggs?

D. Egli, M. Zuccaro, M. Kosicki, G. Church, A. Bradley, M. Jasin

The paper reviews the claim of inter-homologue repair in human embryos using CRISPR-Cas9 and discusses biological constraints and alternative explanations for the observed data.

bioRxiv · Aug 28, 2017Cell Biology

ATR Is Required To Complete Meiotic Recombination In Mice

S. Pacheco, A. Maldonado-Linares, M. Marcet-Ortega, C. Rojas, A. Martinez-Marchal, J. Fuentes-Lazaro, J. Lange, M. Jasin, S. Keeney, O. Fernandez-Capetillo, M. Garcia-Caldes, I. Roig

This study shows ATR is essential for meiotic recombination and prophase completion in mice by promoting RAD51/DMC1 assembly and synapsis.

bioRxiv · May 3, 2017Cell Biology