Author

G. Church

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Bioengineering· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Organism:human· 5 Assay:scRNA-seq· 3 Research Focus:cell-cell communication· 2 Approach:deep learning· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2

Frequent Co-Authors

A. Ashkenazy-Titelman· 1 shared A. Bow· 1 shared A. Bradley· 1 shared A. Garruss· 1 shared A. H. M. Ng· 1 shared A. Kowalczyk· 1 shared A. Lei· 1 shared A. Ng· 1 shared

Activity by Year

2017-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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1 shared paperCell Biology

A. Ashkenazy-Titelman

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Author profile →

8 papers

Recent·Most cited

DERIVATION OF ELEPHANT INDUCED PLURIPOTENT STEM CELLS

E. M. Appleton, K. Hong, C. Rodriguez-Caycedo, Y. Tanaka, A. Ashkenazy-Titelman, K. Bhide, C. Rasmussen-Ivey, X. Ambriz-Pena, N. Korover, H. Bai, A. Quieroz, J. Nelson, G. Rathod, G. Knox, M. Morgan, , E. Hysolli

This paper reports the first derivation of elephant induced pluripotent stem cells (emiPSCs) using a modified reprogramming protocol that inhibits TP53 expansion genes.

bioRxiv · Mar 5, 2024Cell Biology

Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC

S. Liu, L. Li, F. Zhang, B. van Sambeek, E. Appleton, A. H. M. Ng, P. Khoshakhlagh, Y. Chen, M. Garcia-Corral, C.-T. Wu, J. Y. Huang, Y. Tan, G. Chao, J. Aach, J. Tam, , G. Church

This study uses iterative transcription factor screening to generate microglia-like cells from human iPSCs, identifying a combination of TFs that efficiently differentiate iPSCs into microglia-like cells within 4 days.

bioRxiv · Jun 3, 2022Bioengineering

New intranasal and injectable gene therapy for healthy life extension

H. Zhu, D. K. Jaijyan, A. Selariu, R. Cruz-cosme, M. Tong, S. Yang, G. Church, D. Kekich, J. Sadoshima, Q. Tang, E. Parrish

This paper demonstrates that intranasal and injectable CMV-based gene therapy can extend lifespan and improve health in mice by overexpressing TERT and FST.

bioRxiv · Jun 26, 2021Cell Biology

Framework for Rapid Comparison of Extracellular Vesicle Isolation Methods

D. Ter-Ovanesyan, M. Norman, R. Lazarovits, W. Trieu, J. Lee, G. Church, D. R. Walt

The paper compares EV isolation methods using Simoa assays to quantify EV markers and assess efficiency and purity in plasma and CSF.

bioRxiv · Oct 13, 2020Biochemistry

Induced Pluripotent Stem Cell-derived CAR-Macrophage Cells with Antigen-dependent Anti-Cancer Cell Functions for Liquid and Solid Tumors

L. Zhang, L. Tian, X. Dai, H. Yu, J. Wang, A. Lei, W. Zhao, Y. Zhu, Z. Sun, H. Zhang, G. Church, H. Huang, Q. Weng, J. Zhang

The paper develops CAR-expressing iPSC-derived macrophage cells with antigen-dependent anti-cancer functions effective against both liquid and solid tumors.

bioRxiv · Mar 28, 2020 · PreprintCell Biology

Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA

K. Wang, R.-Z. Lin, X. Hong, A. Ng, C.-N. Lee, J. Neumeyer, G. Wang, X. Wang, M. Ma, W. Pu, G. Church, J. Melero-Martin

This study develops a method to efficiently generate human-induced pluripotent stem cell-derived endothelial cells by modulating ETV2 with modified mRNA, achieving high consistency and functionality.

bioRxiv · Mar 2, 2020Cell Biology

Deep Learning for RNA Synthetic Biology

N. Angenent-Mari, A. Garruss, L. R. Soenksen, G. Church, J. Collins

The paper uses deep neural networks to predict toehold switch function in RNA synthetic biology, outperforming existing models and providing visual insights into their behavior.

bioRxiv · Dec 11, 2019 · PreprintBioengineering

Inter-homologue repair in fertilized human eggs?

D. Egli, M. Zuccaro, M. Kosicki, G. Church, A. Bradley, M. Jasin

The paper reviews the claim of inter-homologue repair in human embryos using CRISPR-Cas9 and discusses biological constraints and alternative explanations for the observed data.

bioRxiv · Aug 28, 2017Cell Biology