Author

P. S. Klein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

X. Liu· 3 shared C. Li· 2 shared J. Huang· 2 shared M. Liu· 2 shared A. A. Moverley· 1 shared A. Biju· 1 shared A. Leduc· 1 shared A. Naji· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCell Biology

X. Liu

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Expansion of human hematopoietic stem cells by inhibiting translation

C. Li, H. Shin, D. Bhavanasi, M. Liu, X. Yu, X. Liu, F. Herbst-Nowrouzi, M.-G. Alameh, L. Breda, N. Kovuru, Y. Kwa, N. Sam, S. Rivella, J. R. Alvarez--Dominguez, G. A. Blobel, , P. S. Klein

This paper identifies translation inhibitors that enable ex vivo expansion of human hematopoietic stem cells from umbilical cord blood while maintaining their function and enabling gene editing.

bioRxiv · Nov 28, 2023 · PreprintCell Biology

DEC1 is an adult clock regulator that links circadian rhythms to functional β-cell maturation

Z. Gao, M. Liu, A. P. Montalvo, Z. L. Gruskin, A. Leduc, Y. Xie, S. Preza, J. Du, X. Liu, V. Huhn, Z. Cheng, C. Krapp, M. Haemmerle, A. V. Rozo, X. Wen, , J. R. Alvarez-Dominguez

This study shows DEC1 regulates circadian rhythms in β-cells, linking them to metabolic maturation and glucose responsiveness.

bioRxiv · Aug 11, 2023 · PreprintCell Biology

A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies

X. Liu, S. A. Devadiga, R. F. Stanley, R. Moroow, K. Janssen, M. Quesnel-Vallieres, O. Pomp, A. A. Moverley, C. Li, N. Skuli, M. P. Carroll, J. Huang, D. C. Wallace, K. W. Lynch, O. Abdel-Wahab, P. S. Klein

This study shows that SRSF2 mutations disrupt mitochondrial mRNA splicing, impair complex I function, and increase mitophagy through a PINK1 splicing mechanism, identifying mitophagy as a therapeutic target in MDS and AML.

bioRxiv · Jun 25, 2023 · PreprintCancer Biology