Author

Madelyn J. Blake

Medical University of South Carolina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jeffrey C. BlakeiD· 2 shared Jenna B. MendelsoniD· 2 shared Kurt W. PrinsiD· 2 shared Lynn M. HartweckiD· 2 shared Sandra Breuils‐BonnetiD· 2 shared Steeve ProvencheriD· 2 shared Adam J. BrownsteiniD· 1 shared Candance Guerrero· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Jeffrey C. BlakeORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Impaired Lung BCAA Metabolism Promotes Ferroptosis and Resultant Pulmonary Arterial Hypertension-Associated Hepatopathy

Madelyn J. Blake, Jason S. Hong, Adam J. Brownstein, Christopher J. Rhodes, Emilia M. Swietlik, Jeffrey C. Blake, Ryan A. Moon, Lynn M. Hartweck, Jenna B. Mendelson, Sasha Z. Prisco, Todd W. Markowski, LeeAnn Higgins, Kevin J. Murray, Candance Guerrero, Sandra Breuils‐Bonnet, , Kurt W. Prins

This study shows that impaired BCAA metabolism promotes ferroptosis, leading to pulmonary arterial hypertension and associated liver disease, and that targeting BCAA metabolism can alleviate these effects.

JACC Basic to Translational Science · May 30, 2026Peer-reviewedMolecular Biology

Pulmonary Arterial Hypertension Induces a Metabolic and Inflammatory Hepatopathy

Madelyn J. Blake, Sally Prins, Jeffrey C. Blake, Lynn M. Hartweck, Jenna B. Mendelson, Steeve Provencher, Sandra Breuils‐Bonnet, Sébastien Bonnet, Kurt W. Prins

This study identifies metabolic and inflammatory changes in the liver of PAH patients using single nucleus RNA sequencing, revealing distinct cellular phenotypes and signaling pathways.

Journal of Clinical Investigation · May 28, 2026Peer-reviewedBiochemistry