Modulating DNA Polα Enhances Cell Reprogramming Across Species
Rajesh Ranjan, Binbin Ma, Ryan J. Gleason, Yijun Liao, Yingshan Bi, Brendon E. M. Davis, Guanghui Yang, Maggie Clark, Vikrant Mahajan, Madison Condon, Nichole A. Broderick, Xin Chen
This study shows that reducing DNA Polα levels enhances cell reprogramming across species, improving fertility and tissue regeneration without affecting lifespan.
bioRxiv · Sep 19, 2024 · PreprintDevelopmental Biology