Xin Chen

Transient low-dose inhibition of DNA polymerase α enhances human cell reprogramming by promoting chromatin plasticity while maintaining genomic stability.

This study shows that asymmetric histone inheritance in olfactory stem cells during regeneration affects cell fate and tissue repair in mice.

The paper develops a Wnt-induced osteogenic tissue model (WIOTM) that sustains H3K14-acetylation in human skeletal stem cells, promoting bone repair through asymmetric cell division.

The paper identifies histone H4 as a repressor of histone gene transcription during G2 phase in germline cells, showing conserved repression across Drosophila and human cells.

The paper shows maternal CENP-C restores centromere symmetry in zygotes by asymmetrically recruiting to paternal centromeres, ensuring proper chromosome segregation.

This study shows that reducing DNA Polα levels enhances cell reprogramming across species, improving fertility and tissue regeneration without affecting lifespan.

This study shows that the Drosophila SET1 histone methyltransferase regulates male germline stem cell maintenance and differentiation by coordinating JAK-STAT and BMP signaling pathways.

The paper shows that reduced levels of lagging strand polymerases in stem cells lead to asymmetric histone incorporation, which can be induced in progenitor cells through genetic or chemical manipulation.

The paper tracks CENP-A dynamics in mouse gametes and embryos, showing sex-specific differences in centromere maintenance and equalization during early development.

This study shows that the N-terminal amino acid difference between H3 and H3.3 in Drosophila male germline stem cells affects their inheritance patterns and function in stem cell maintenance and differentiation.

The paper shows that an epigenome switch from H3 to H3.3 to H3 during C. elegans development is essential for germline integrity and early embryonic plasticity.

The paper characterizes histone inheritance patterns in Drosophila female germline asymmetric divisions, showing differential inheritance at genes related to stem cell maintenance and differentiation.

This study shows that asymmetric histone inheritance in Drosophila male germline stem cells leads to differential chromosomal condensation and Cdc6 association, affecting cell cycle progression and fate decisions.

This study shows asymmetric histone inheritance in Drosophila intestinal stem cells influences daughter cell fate, with mutant histones leading to increased symmetric division and tumors.

The paper shows that histone H4 is asymmetrically inherited in Drosophila male germline stem cells during asymmetric division, while H2A and H2B are symmetrically inherited.

The paper shows that stem cell mitotic drive ensures asymmetric sister chromatid attachment and segregation through epigenetic differences at sister centromeres.