SIX1-dependent myofiber typology and metabolism controls muscle hypertrophy
Maxime Di Gallo, Léa Delivry, Doriane Pereira, Edgar Jauliac, Gaspard Macaux, Thomas Guilbert, R Denis, Stéphanie Backer, Madison Saintpierre, Lucie Adoux, Romain Bernasconi, Martin Laasmaa, Rikke Birkedal, Marko Vendelin, Matthieu Dos Santos, , Florian Alexis Britto
This study shows that SIX1 regulates muscle fiber hypertrophy by modulating metabolism and fiber type transitions in response to mechanical overload.
bioRxiv · Feb 5, 2026 · PreprintPhysiology