Stéphanie Backer

REDD1 Regulates MERCS, Protein Synthesis and NMJ Stability in Fast Myofibers During Dexamethasone-Induced Muscle Wasting

EYA1/EYA2 and EYA3/EYA4 act as stage-specific SIX cofactors in embryonic and adult regenerative skeletal myogenesis

This study investigates the role of EYA1/EYA2 and EYA3/EYA4 in skeletal myogenesis, showing that EYA3/EYA4 are critical for adult muscle regeneration while EYA1/EYA2 are essential for embryonic development.

Identification of a new population of myonuclei during skeletal muscle hypertrophy

The paper identifies a new population of myonuclei during skeletal muscle hypertrophy using snRNA-seq and RNAscope, showing distinct localization and gene expression profiles.

c-MAF transduces fast motor neuron firing to sustain fast-glycolytic myofibers and neuromuscular junctions

This study identifies c-MAF as a mediator of motoneuron activity in maintaining fast-glycolytic muscle fibers and neuromuscular junctions through chromatin accessibility changes and gene regulation.

SIX1-dependent myofiber typology and metabolism controls muscle hypertrophy

This study shows that SIX1 regulates muscle fiber hypertrophy by modulating metabolism and fiber type transitions in response to mechanical overload.

Both GEF domains of the autism and epilepsy-associated Trio protein are required for proper tangential migration of GABAergic interneurons

This study shows that both GEF domains of the Trio protein are essential for proper tangential migration of GABAergic interneurons, with GEFD2 playing a dominant role.