Author

Madyson E. Ashcraft

West Virginia University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Brooke A. BrothersiD· 2 shared Lee M. Shaw· 2 shared Marion E. Cahill· 2 shared Tongju Guan· 2 shared Wen‐Tao DengiD· 2 shared Artjola PujaiD· 1 shared Becky Chen· 1 shared Emily R. SechrestiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMolecular Biology

Brooke A. BrothersORCID

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2 papers

Recent·Most cited

Gene Therapy Rescues Cone Function in an All-cone Retina Mouse Model for Blue Cone Monochromacy with the Most Common C203R Missense Mutation

Marion E. Cahill, Kathryn Chmelik, Brooke A. Brothers, Madyson E. Ashcraft, Tongju Guan, Artjola Puja, Yinxiao Xiang, Lee M. Shaw, Jianhai Du, Wen‐Tao Deng

This study shows gene therapy can restore cone function and structure in a mouse model of blue cone monochromacy with the C203R mutation.

bioRxiv · Sep 4, 2025 · PreprintMolecular Biology

Molecular Mechanisms Limiting the Therapeutic Window of AAV Gene Therapy in Mouse Models of Blue Cone Monochromacy

Brooke A. Brothers, Emily R. Sechrest, Li Ma, Madyson E. Ashcraft, Tongju Guan, Robert J. Barbera, Marion E. Cahill, Lee M. Shaw, Becky Chen, Wolfgang Baehr, Gangqing Hu, Peter Stoilov, Wen‐Tao Deng

This study evaluates AAV gene therapy in BCM mouse models, finding that older mutant mice show reduced treatment efficacy due to decreased transduction and cone degeneration, while specific promoters remain active.

bioRxiv · Feb 14, 2025 · PreprintMolecular Biology