Wen‐Tao Deng

Mapping the chaperonin TRiC/CCT interactome in mouse photoreceptors reveals functional significance for energy metabolism

The paper maps the TRiC/CCT interactome in mouse photoreceptors and identifies its role in energy metabolism and neurodegeneration.

Super-resolution microscopy reveals a Rab6a-dependent trafficking hub for rhodopsin at the mammalian rod photoreceptor Golgi

This study uses super-resolution microscopy to show that Rab6a regulates rhodopsin trafficking from the trans-Golgi in mammalian rod photoreceptors, with implications for retinal health.

Gene Therapy Rescues Cone Function in an All-cone Retina Mouse Model for Blue Cone Monochromacy with the Most Common C203R Missense Mutation

This study shows gene therapy can restore cone function and structure in a mouse model of blue cone monochromacy with the C203R mutation.

Molecular Mechanisms Limiting the Therapeutic Window of AAV Gene Therapy in Mouse Models of Blue Cone Monochromacy

This study evaluates AAV gene therapy in BCM mouse models, finding that older mutant mice show reduced treatment efficacy due to decreased transduction and cone degeneration, while specific promoters remain active.

P23H rhodopsin aggregation in the ER causes synaptic protein imbalance in rod photoreceptors

This study investigates how mislocalized P23H rhodopsin affects synaptic protein levels in rod photoreceptors using mouse models and proteomics.