Humanized glioblastoma patient-derived orthotopic xenografts recreate a locally immunosuppressed human immune ecosystem amenable to immunotherapeutic modulation
Pilar M. Moreno‐Sanchez, Anaïs Oudin, Batuhan Kısakol, Heiko Düßmann, Eliane Klein, Virginie Baus, Camille Rolin, Carole Seguin‐Devaux, Mahsa Rezaeipour, Aurélie Poli, Alessandro Michelucci, Jérôme Paggetti, Etienne Moussay, Jochen H.M. Prehn, Simone P. Niclou, Anna Golebiewska
This study develops humanized glioblastoma PDOX models to study tumor-immune interactions and test immunotherapies in a human context.
bioRxiv · Nov 20, 2025 · PreprintCancer Biology