Batuhan Kısakol

Cell engulfment defines spatially distinct competitive metabolic niches associated with clinical outcomes in colorectal cancer

The paper investigates cell engulfment in colorectal cancer, showing it creates competitive metabolic niches linked to clinical outcomes.

A neural network model delivers a highly prognostic protein signature in cancer stem cells that identifies relapse in stage III colorectal cancer patients.

This paper identifies a five-protein stem cell signature using a deep neural network that predicts relapse in stage III colorectal cancer patients.

Spatiotemporal dynamics of Mcl-1 abundance and its influence on apoptosis susceptibility

This study shows Mcl-1 accumulation and redistribution during the cell cycle increase MOMP thresholds, contributing to cell-to-cell variability in apoptosis susceptibility and intra-tumour heterogeneity.

Humanized glioblastoma patient-derived orthotopic xenografts recreate a locally immunosuppressed human immune ecosystem amenable to immunotherapeutic modulation

This study develops humanized glioblastoma PDOX models to study tumor-immune interactions and test immunotherapies in a human context.

High-Resolution Spatial Proteomics Characterises Colorectal Cancer Consensus Molecular Subtypes

This study uses high-resolution spatial proteomics to characterize colorectal cancer consensus molecular subtypes at single-cell resolution, revealing subtype-specific immune and metabolic features.