LRRK2/LRRK1 interactions modulate Rab7 activity and inhibit lysosomal exocytosis
Madiha Mohieldin Merghani, Ellen Gerhardt, Maiken Hesse, Christiane Fahlbusch, C. Alexander Boecker, Tiago F. Outeiro
This study investigates the interaction between LRRK1 and LRRK2, showing they modulate Rab7 activity and lysosomal exocytosis, with starvation reducing their interaction and impairing lysosomal homeostasis.
bioRxiv · Jun 15, 2026 · PreprintCell Biology