Ellen Gerhardt

This study investigates the interaction between LRRK1 and LRRK2, showing they modulate Rab7 activity and lysosomal exocytosis, with starvation reducing their interaction and impairing lysosomal homeostasis.

This study identifies cofilin dysregulation as a mediator of α-synuclein-induced synaptic dysfunction in hippocampal neurons in synucleinopathy models.

This study models aSyn assemblies in living cells and shows that Sph1-aSyn interactions influence inclusion formation, morphology, and localization, providing insights into protein aggregation and potential therapeutic strategies.

This study compares the release and effects of alpha-synuclein, Tau, and huntingtin in neuronal cells, showing similar release pathways and impacts on neuronal activity and inflammation.

The paper characterizes ectosomes and exosomes proteomes and shows they modulate neuronal activity differently.