FABP4-mediated lipid accumulation and lipolysis in tumor associated macrophages promote breast cancer metastasis
Matthew S. Yorek, Xingshan Jiang, Shanshan Liu, Jiaqing Hao, Jianyu Yu, Anthony Avellino, Zhanxu Liu, Melissa A. Curry, Henry L. Keen, Jianqiang Shao, Anand Kanagasabapathy, Maiying Kong, Yiqin Xiong, Edward R. Sauter, Sonia L. Sugg, Bing Li
This study shows that FABP4 in tumor-associated macrophages promotes breast cancer metastasis by mediating lipid accumulation and lipolysis in response to unsaturated fatty acids.
eLife · Oct 1, 2024Peer-reviewedImmunology