Jianyu Yu

Keratinocyte FABP5 mediates saturated fat-induced MAPK/CCL20 signaling in psoriatic inflammation

FABP4 Couples Lipid Metabolism to PD-L1 Stabilization in Immunosuppressive Macrophages

This study identifies a FABP4-PD-L1 axis linking lipid metabolism to immune suppression in macrophages, showing FABP4 enables PD-L1 stabilization and correlates with obesity and breast cancer.

Targeting Circulating FABP4 Ameliorates Obesity-Associated Hepatic Steatosis

This study identifies circulating FABP4 as a mediator of adipocyte-hepatocyte lipid crosstalk in obesity and shows that targeting it with a monoclonal antibody reduces hepatic steatosis in mouse models.

FABP5 in Skin Macrophages Mediates Saturated Fat-Induced IL-1β Signaling in Obesity-Associated Psoriasis Development

This study shows that saturated fats drive psoriasis via FABP5-mediated IL-1β/IL-17 signaling in skin macrophages, exacerbating obesity-associated psoriasis.

Expression Profiles of FABP4 and FABP5 in Breast Cancer: Clinical Implications and Perspectives

This study examines FABP4 and FABP5 expression in breast cancer tissues, finding distinct roles in tumor progression and suggesting their potential as prognostic markers and therapeutic targets.

FABP4-mediated lipid accumulation and lipolysis in tumor associated macrophages promote breast cancer metastasis

This study shows that FABP4 in tumor-associated macrophages promotes breast cancer metastasis by mediating lipid accumulation and lipolysis in response to unsaturated fatty acids.

Development of a humanized anti-FABP4 monoclonal antibody for treatment of breast cancer

This paper develops humanized anti-FABP4 monoclonal antibodies that inhibit breast cancer tumor growth and metastasis by targeting FABP4's role in lipid metabolism.