FABP5 in Skin Macrophages Mediates Saturated Fat-Induced IL-1β Signaling in Obesity-Associated Psoriasis Development
Jianyu Yu, Jiaqing Hao, Matthew S. Yorek, Xingshan Jiang, Anthony Avellino, Shanshan Liu, Xiaochun Han, Jonathan S. Shilyansky, Zhaohua Wang, Yuhang Wang, Zizhen Kang, Ali Jabbari, Bing Li
This study shows that saturated fats drive psoriasis via FABP5-mediated IL-1β/IL-17 signaling in skin macrophages, exacerbating obesity-associated psoriasis.
Cell Reports · Sep 1, 2025Peer-reviewedImmunology