Modeling Friedreich's ataxia with Bergmann glia-enriched human cerebellar organoids
Seungmi Ryu, Jason M. Inman, Hyenjong Hong, Vukasin M. Jovanovic, Qiang Chen, Yeliz Gedik, Yogita Jethmalani, Inae Hur, Majid Harouni, Ty C. Voss, Justin Lack, Jack Collins, Pinar Ormanoglu, Anton M. Simeonov, Carlos A. Tristan, Ilyas Singeç
This paper develops a human cerebellar organoid model that recapitulates cerebellar development and reveals disease-specific phenotypes in Friedreich's ataxia.
Communications Biology · May 7, 2026Peer-reviewedDevelopmental Biology