Mature tumoroids recapitulate clinically relevant drug response through extended 3D culture in PDAC
Krzysztof Kuś, David L. Earnshaw, Artur Piróg, Martyna Siewiera, Sachin Kote, Aleksandra Anna Murzyn, Piotr Świerzewski, Natalia Malek-Trzonkowska, Zuzanna Sandowska-Markiewicz, Katarzyna Unrug-Bielawska, Malgorzata Statkiewicz, Paola Dama, Marcin Przemysław Krzykawski
This study shows that mature tumoroids, grown in 3D culture for ≥10 days, better reflect clinical drug responses in PDAC compared to short-term cultures by capturing microenvironmental effects and transporter-mediated resistance.
bioRxiv · Apr 7, 2026 · PreprintCancer Biology