Krzysztof Kuś

This study shows that reducing Integrator complex activity in adult C. elegans extends lifespan and healthspan by disrupting RNA processing and mitochondrial function.

This study shows that mature tumoroids, grown in 3D culture for ≥10 days, better reflect clinical drug responses in PDAC compared to short-term cultures by capturing microenvironmental effects and transporter-mediated resistance.

This study shows that the PP1 phosphatase complex coordinates pre-mRNA 3' end processing and RNA polymerase II transcription termination through interactions with PNUTS and Symplekin.

This study attempts to use antisense inhibition to analyze gene function in an obligate symbiosis but concludes it is not feasible due to holobiont growth in response to antisense treatment.

This study shows that Spt5 enhances Xrn2 activity to facilitate Pol II transcription termination and prevent non-coding transcript expression.

This study shows that 3D cultures of pancreatic cancer cells better replicate the mitochondrial oxidative phosphorylation genotype seen in vivo compared to 2D cultures.

The paper identifies Mub1 as an RNA-binding protein that regulates exosome-dependent mRNA degradation, affecting stress response and gene expression.

The paper uses poly(A)+ RNA-protein crosslinking data in fission yeast to analyze RNA-protein complexes and their functional organization.

The paper shows that HDAC-dependent histone deacetylation is critical for transcriptional silencing of facultative heterochromatin in fission yeast.