Author

David L. Earnshaw

ORCID 0000-0002-0650-1362Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Katarzyna Unrug-BielawskaiD· 2 shared Krzysztof KuśiD· 2 shared Marcin Przemysław KrzykawskiiD· 2 shared Zuzanna Sandowska-Markiewicz· 2 shared Aleksandra Anna MurzyniD· 1 shared Artur PirógiD· 1 shared Beata BiesagaiD· 1 shared J. Mark TreherneiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

Katarzyna Unrug-BielawskaORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Mature tumoroids recapitulate clinically relevant drug response through extended 3D culture in PDAC

Krzysztof Kuś, David L. Earnshaw, Artur Piróg, Martyna Siewiera, Sachin Kote, Aleksandra Anna Murzyn, Piotr Świerzewski, Natalia Malek-Trzonkowska, Zuzanna Sandowska-Markiewicz, Katarzyna Unrug-Bielawska, Malgorzata Statkiewicz, Paola Dama, Marcin Przemysław Krzykawski

This study shows that mature tumoroids, grown in 3D culture for ≥10 days, better reflect clinical drug responses in PDAC compared to short-term cultures by capturing microenvironmental effects and transporter-mediated resistance.

bioRxiv · Apr 7, 2026 · PreprintCancer Biology

3D culture of pancreatic cancer cells in vitro recapitulates an aberrant mitochondrial oxidative phosphorylation genotype observed in vivo

Krzysztof Kuś, J. Mark Treherne, David L. Earnshaw, Renata Krzykawska, Beata Biesaga, Małgorzata Statkiewicz, Katarzyna Unrug-Bielawska, Zuzanna Sandowska-Markiewicz, Michał Mikuła, Javier Antonio Alfaro, Marcin Przemysław Krzykawski

This study shows that 3D cultures of pancreatic cancer cells better replicate the mitochondrial oxidative phosphorylation genotype seen in vivo compared to 2D cultures.

bioRxiv · Mar 8, 2024 · PreprintCancer Biology