Shon A. Koren

Neuronal activity triggers widespread changes in RNA stability

The paper shows neuronal activity affects RNA stability, with HuD regulating mRNA abundance and variants linked to neurodevelopmental disorders disrupting this process.

All-optical spatiotemporal mapping of ROS dynamics across mitochondrial microdomains in situ

The paper maps ROS dynamics in mitochondrial microdomains using all-optical methods to study spatiotemporal H2O2 diffusion and its effects on mitochondrial behavior.

BAG3 regulation of Rab35 mediates the Endosomal Sorting Complexes Required for Transport /endolysosome pathway and tau clearance

This study identifies a BAG3-TBC1D10B-Rab35 regulatory axis that modulates ESCRT-dependent tau clearance and links its dysfunction to Alzheimer's disease pathogenesis.

Broad kinase inhibition mitigates early neuronal dysfunction and cognitive deficits in tauopathy

The paper treats early-stage tau transgenic mice with a multi-target kinase inhibitor, showing cognitive improvement and proteomic shifts similar to Alzheimer's disease in humans.