Nik Matthews

This paper identifies a microbiota-responsive polyfunctional cytotoxic CD4⁺ T-cell state linked to mucosal inflammation and treatment resistance in ulcerative colitis.

The paper identifies a stromal remodelling programme in ulcerative colitis patients who failed prior anti-TNF therapy, linking it to MAPK/EGFR signalling and suggesting MEK/EGFR inhibitors as potential treatments.

This study identifies KLF6 as a key driver of endothelial dysfunction in pulmonary arterial hypertension, showing its role in promoting vascular remodelling and angioproliferative lesions.

This study uses spatial transcriptomics to compare gene expression in ovarian clear cell carcinoma and adjacent endometriosis across UK and Japanese patients, finding distinct transcriptional patterns by tissue compartment rather than geographic origin.

The paper uses multimodal imaging to show that lysosomes act as a reservoir for PARP inhibitors, leading to heterogeneous drug distribution and response in ovarian cancer.

The paper constructs a single-cell atlas of fetal Down syndrome cortex, identifying chromosome 21 transcription factors that regulate intellectual disability gene networks and showing their normalization can restore molecular signatures.

The paper uses spatial multiomic profiling to identify distinct fibrotic epithelial niches in IPF, revealing a KRT5low/KRT17 epithelial population and its association with SPP1 macrophages.

This paper develops an error-corrected cfDNA sequencing method for highly sensitive mutation detection and genome-wide copy number reconstruction in metastatic colorectal cancer.