Heterooligomerization drives structural plasticity of eukaryotic peroxiredoxins
Jannik Zimmermann, Lukas Lang, Julia Malo Pueyo, Mareike Riedel, Khadija Wahni, Dylan Stobbe, Christopher Lux, Steven Janvier, Didier Vertommen, Svenja Lenhard, Frank Hannemann, Helena Castro, Ana M. Tomás, Johannes M. Herrmann, Armindo Salvador, , Bruce Morgan
The paper shows that eukaryotic Prx1/AhpC-type peroxiredoxins form heterooligomers, which modulate their structure and stability, challenging the previous belief in homooligomerization.
bioRxiv · Mar 3, 2025 · PreprintBiochemistry