Author

Marel F.M. Spoelstra

Utrecht University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Anna S. AkhmanovaiD· 3 shared Kelly E. SteckeriD· 3 shared Dipti RaiiD· 2 shared Adela KarhanovaiD· 1 shared Alex Moore· 1 shared Andressa Pelster Jose· 1 shared Bert Jan Korte· 1 shared Daan Morren· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCell Biology

Anna S. AkhmanovaORCID

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3 papers

Recent·Most cited

Dissection of centrosomal γ-TuRC activation pathways controlling microtubule density in interphase cells

Yinlong Song, Dipti Rai, Lilian M. Sluimer, Marel F.M. Spoelstra, Quinten J. Kleijnen, Bert Jan Korte, Silas T. Koot, Kelly E. Stecker, Fangrui Chen, Anna S. Akhmanova

The paper investigates pathways controlling microtubule density in interphase cells by disrupting CAMSAP and γ-TuRC pathways, revealing redundant activation mechanisms.

bioRxiv · Aug 19, 2026 · PreprintCell Biology

Regulation of microtubule abundance and minus end dynamics by Katanin, CAMSAPs, WDR47 and kinesin-13

Dipti Rai, Elena Radul, Shasha Hua, Marel F.M. Spoelstra, Eugene A. Katrukha, Kelly E. Stecker, Kai Jiang, Anna S. Akhmanova

This study investigates how Katanin, CAMSAPs, WDR47, and kinesin-13 regulate microtubule abundance and minus-end dynamics through in vitro reconstitution.

bioRxiv · Mar 26, 2026 · PreprintCell Biology

Taxane-Induced Conformational Changes in the Microtubule Lattice Activate GEF-H1-Dependent RhoA Signaling

Joyce C. M. Meiring, Varsha Mahapatra, Molly S. C. Gravett, Daan Morren, Harriet A. J. Saunders, Sung Ryul Choi, Andressa Pelster Jose, Adela Karhanova, Ioanna Metallidou, Alex Moore, Marel F.M. Spoelstra, Ruijie Liu, Matteo Giono, Saishree S. Iyer, J. Fernando Díaz, , Anna S. Akhmanova

This study shows taxanes induce conformational changes in microtubules, releasing GEF-H1 and activating RhoA signaling, leading to actin remodeling.

bioRxiv · Dec 23, 2025 · PreprintCell Biology