Taxane-Induced Conformational Changes in the Microtubule Lattice Activate GEF-H1-Dependent RhoA Signaling
Joyce C. M. Meiring, Varsha Mahapatra, Molly S. C. Gravett, Daan Morren, Harriet A. J. Saunders, Sung Ryul Choi, Andressa Pelster Jose, Adela Karhanova, Ioanna Metallidou, Alex Moore, Marel F.M. Spoelstra, Ruijie Liu, Matteo Giono, Saishree S. Iyer, J. Fernando Díaz, , Anna S. Akhmanova
This study shows taxanes induce conformational changes in microtubules, releasing GEF-H1 and activating RhoA signaling, leading to actin remodeling.
bioRxiv · Dec 23, 2025 · PreprintCell Biology