Eomes and Brachyury control pluripotency exit and germ layer segregation by changes of chromatin state
Jelena Tošić, Gwang-Jin Kim, Mihael Pavlovic, Chiara M. Schröder, Sophie‐Luise Mersiowsky, Margareta Barg, Alexis Hofherr, Simone Probst, Michael Köttgen, Lutz Hein, Sebastian J. Arnold
This study shows that Eomes and Brachyury control pluripotency exit and germ layer segregation by altering chromatin states, with Tbx factors repressing pluripotency and NE gene programs while enabling ME differentiation.
Nature Cell Biology · Dec 1, 2019Peer-reviewedDevelopmental Biology