Jelena Tošić

The paper investigates the spatiotemporal sequence of mesoderm and endoderm lineage segregation during mouse gastrulation using genetic fate labeling, imaging, and scRNA-seq.

This study shows that Eomes and Brachyury control pluripotency exit and germ layer segregation by altering chromatin states, with Tbx factors repressing pluripotency and NE gene programs while enabling ME differentiation.