Simone Probst

The paper identifies two regulatory modules that control the sequential transition between early and late gastrulation modes in mouse gastruloids.

The paper investigates the distinct gene-regulatory functions of Eomes and Brachyury in mouse embryos and stem cells, showing Eomes restricts Brachyury activity to ensure proper lineage specification.

The paper identifies EOMES-induced chromatin accessibility as a key step in initiating mesendoderm lineage commitment during mammalian gastrulation.

This paper introduces chimeric 3D-gastruloids as a tool to study mammalian peri-gastrulation development by combining genetically distinct cells to investigate gene function and phenotypes.

The paper investigates the spatiotemporal sequence of mesoderm and endoderm lineage segregation during mouse gastrulation using genetic fate labeling, imaging, and scRNA-seq.

This study shows that Eomes and Brachyury control pluripotency exit and germ layer segregation by altering chromatin states, with Tbx factors repressing pluripotency and NE gene programs while enabling ME differentiation.