Author

Sophie‐Luise Mersiowsky

University of FreiburgORCID 0000-0001-9675-2175Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Chiara M. SchröderiD· 2 shared Sebastian J. ArnoldiD· 2 shared Simone ProbstiD· 2 shared Alexis HofherriD· 1 shared Gwang-Jin KimiD· 1 shared H. T. Marc TimmersiD· 1 shared Jelena TošićiD· 1 shared Katrin M. SchüleiD· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersDevelopmental Biology

Chiara M. SchröderORCID

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2 papers

Recent·Most cited

An EOMES induced epigenetic deflection initiates lineage commitment at mammalian gastrulation

Chiara M. Schröder, Lea Zissel, Sophie‐Luise Mersiowsky, Mehmet Tekman, Simone Probst, Katrin M. Schüle, Sebastian Preißl, Oliver Schilling, H. T. Marc Timmers, Sebastian J. Arnold

The paper identifies EOMES-induced chromatin accessibility as a key step in initiating mesendoderm lineage commitment during mammalian gastrulation.

bioRxiv · Mar 15, 2023 · PreprintDevelopmental Biology

Eomes and Brachyury control pluripotency exit and germ layer segregation by changes of chromatin state

Jelena Tošić, Gwang-Jin Kim, Mihael Pavlovic, Chiara M. Schröder, Sophie‐Luise Mersiowsky, Margareta Barg, Alexis Hofherr, Simone Probst, Michael Köttgen, Lutz Hein, Sebastian J. Arnold

This study shows that Eomes and Brachyury control pluripotency exit and germ layer segregation by altering chromatin states, with Tbx factors repressing pluripotency and NE gene programs while enabling ME differentiation.

Nature Cell Biology · Dec 1, 2019Peer-reviewedDevelopmental Biology