A multivalent mRNA-LNP therapeutic vaccine with broad cross-genotype immunogenicity elicits clearance of HBV infected hepatocytes
Daniel L. Makrinos, Yanbo Sun, Heather L. Davis, LingZhi Ma, Thu Kim, Emma Dellea, Mia Malone, Edison Ong, Maria Cavallaro, Caroline G. Atyeo, Phillipa Martin, Cathal Harmon, Ziqiu Wang, Guha Asthagiri Arunkumar, Alec W. Freyn, , Simone Pecetta
This paper develops an mRNA-LNP vaccine, mRNA-1965, that clears HBV-infected hepatocytes in mice by inducing broad immune responses across HBV genotypes.
bioRxiv · Dec 5, 2025 · PreprintImmunology