The tumor suppressor p53 mutational status controls epithelial 3D cell growth under mechanical compression
Mickaël Di‐Luoffo, Silvia Arcucci, Nicole Therville, Tristan Marty, Romina D’Angelo, Maria Chaouki, Benoît Thibault, Pascal Swider, Pauline Assémat, Morgan Delarue, Julie Guillermet‐Guibert
This study shows that p53 mutations enhance cancer cell survival and growth under mechanical compression, suggesting p53 status as a biomarker for tumor adaptation to stress.
bioRxiv · Oct 23, 2025 · PreprintCancer Biology