Morgan Delarue

The paper introduces two microfluidic devices for applying and measuring growth-induced pressure on microbes, enabling single-cell imaging and bulk biochemical analysis under controlled conditions.

The paper identifies the stimulus activating the fgMAPK pathway in yeast filamentous growth and links TOR pathway regulation of Gln3 to cell elongation.

This study shows that bacterial growth under confinement leads to increased turgor pressure, which disrupts division and protein synthesis, and activates the Rcs pathway, with implications for infection physiology.

The paper introduces Selective Laser Etching (SLE) for creating 3D microfluidic and electrochemical devices, demonstrating its use in fabricating functional sliding elements for reconfigurable chips.

The paper observes decreased molecular crowding during yeast to filamentous growth transition in C. albicans, linked to reduced ribosome concentration and increased cytoplasmic volume.

This study shows that p53 mutations enhance cancer cell survival and growth under mechanical compression, suggesting p53 status as a biomarker for tumor adaptation to stress.

The paper examines how compressive stress affects proliferation and motility in pancreatic cancer cell lines, finding that mesenchymal phenotypes show greater sensitivity to compression.

This study tracks ribosome-sized particles in E. coli to show that their 3D diffusion is influenced by macromolecular interactions and geometrical confinement, revealing sub-diffusive motion due to nucleoid and cell boundary constraints.

The paper shows that mechanical compression increases PI3K signaling in breast and pancreatic cancer cells, enhancing resistance to PI3K inhibitors and affecting autophagy.

This study measures intracellular dry mass density in yeast under growth-induced pressure and finds it correlates with macromolecule accumulation and osmolyte concentration.