Author

N. Therville

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Pathology· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2

Frequent Co-Authors

B. Thibault· 3 shared C. Cayron· 3 shared J. Guillermet-Guibert· 3 shared A. Carrier· 2 shared A. V. Villard· 2 shared Benoît ThibaultiD· 2 shared C. Basset· 2 shared C. Cintas· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

B. Thibault

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Autophagy driven by VPS34 enables differentiated cell plasticity and cancer initiation

Fernanda Ramos‐Delgado, Hala Shalhoub, Camille Guyon, Charles Handschin, Pablo Cerapio-Arroyo, R. D’Angelo, N. Therville, Amélie V. Villard, Coralie Cayron, Carine Valle, Émeline Sarot, Nathalie Dusserre, Mickaël Di‐Luoffo, Vinciane Rebours, Anne Couvelard, , Julie Guillermet‐Guibert

This study shows that VPS34-driven autophagy restricts cancer initiation by preventing transdifferentiation and reducing oncogenic KRAS promotion in pancreatic acinar cells.

bioRxiv · May 2, 2025 · PreprintPathology

Mechanical compressive forces increase PI3K output signaling in breast and pancreatic cancer cells

Mickaël Di‐Luoffo, Céline Schmitter, Emma C Barrere, N. Therville, Maria Chaouki, Romina D’Angelo, Silvia Arcucci, Benoît Thibault, Morgan Delarue, Julie Guillermet‐Guibert

The paper shows that mechanical compression increases PI3K signaling in breast and pancreatic cancer cells, enhancing resistance to PI3K inhibitors and affecting autophagy.

Life Science Alliance · Jan 2, 2025Peer-reviewedCancer Biology

Meat enriched-diet and inflammation promote PI3Kα-dependent pancreatic cell plasticity that limit tissue regeneration.

C. Cayron, D. Bozoglou, A. V. Villard, G. Reyes-Castellanos, N. Therville, R. Baer, S. Arcucci, N. Naud, M. Tosolini, F. Pont, D. Ferreira Da Mota, F. Gueraud, C. Basset, A. Carrier, F. Pierre, , J. Guillermet-Guibert

This study shows that meat-enriched diets and inflammation promote pancreatic cell plasticity via PI3Kα, which limits tissue regeneration and increases cancer risk.

bioRxiv · Aug 22, 2023 · PreprintPathology

Phosphoproteomics identifies PI3K inhibitor-selective adaptive responses in pancreatic cancer cell therapy and resistance

C. Cintas, T. Douche, Z. Dantes, E. Mouton-Barbosa, M.-P. Bousquet, C. Cayron, N. Therville, F. Pont, F. Ramos-Delgado, C. Guyon, B. Garmy-Susini, P. Cappello, O. Burlet-Schiltz, E. Hirsch, A. Gomez-Brouchet, , J. Guillermet-Guibert

This study identifies adaptive phosphoprotein responses to isoform-selective PI3K inhibitors in pancreatic cancer, showing that combination therapy can overcome resistance.

bioRxiv · Oct 8, 2020Cancer Biology

Pancreatic Cancer Intrinsic PI3Kα Activity accelerates Metastasis and rewires Macrophage Component

B. Thibault, F. Ramos-Delgado, E. Pons-Tostivint, N. Therville, C. Cintas, S. Arcucci, S. Cassant-Sourdy, G. Reyes-Castellanos, M. Tosolini, A. V. Villard, C. Cayron, R. Baer, J. Bertrand-Michel, D. Payen, H. Yan, , J. Guillermet-Guibert

This paper identifies PI3K pathway activation as a driver of metastatic progression in pancreatic cancer and shows that targeting PI3K can delay macro-metastatic evolution.

bioRxiv · Sep 23, 2020Cancer Biology