Mickaël Di‐Luoffo

This study shows that p53 mutations enhance cancer cell survival and growth under mechanical compression, suggesting p53 status as a biomarker for tumor adaptation to stress.

This study shows cancer cells follow intrinsic self-organized programs that coordinate tumor cell state transitions during growth, revealing mechanical gradients and stereotyped patterns of heterogeneity and plasticity.

This study shows that VPS34-driven autophagy restricts cancer initiation by preventing transdifferentiation and reducing oncogenic KRAS promotion in pancreatic acinar cells.

The paper shows that mechanical compression increases PI3K signaling in breast and pancreatic cancer cells, enhancing resistance to PI3K inhibitors and affecting autophagy.