Novel, small molecules targeting the 5-HT4R receptor protect against stress-induced maladapative behavior with efficacy across age
Rebecca Ravenelle, Shi‐Xian Deng, Mel Nelson, Maria H. Pedersen, Indira Mendez‐David, Denis Joseph Paul David, Victor M. Luna, Gergely F. Turi, Madeline Abramson, Jonathan A. Javitch, Donald W. Landry, Briana K. Chen, Christine Ann Denny
The paper develops and tests novel 5-HT4R-targeting compounds that reduce stress-induced maladaptive behaviors in mice, showing efficacy across age groups.
bioRxiv · Oct 8, 2025 · PreprintNeuroscience