Repurposing cell growth-regulating compounds identifies kenpaullone which ameliorates pathologic pain via normalization of inhibitory neurotransmission
Michele Yeo, Yong Chen, Changyu Jiang, Gang Chen, Kaiyuan Wang, Andrey V. Bortsov, Maria Lioudyno, Qian Zeng, Zilong Wang, Jorge A. Busciglio, Ru‐Rong Ji, Wolfgang Liedtke
The paper identifies kenpaullone as a compound that enhances KCC2 expression and reduces pathologic pain by restoring inhibitory neurotransmission in mouse models.
bioRxiv · Mar 19, 2020 · PreprintNeuroscience