Wolfgang Liedtke

This study investigates the acute effects of static magnetic fields on excitatory synaptic activity in rat motor cortex neurons using patch-clamp recordings.

This study shows that knocking out Piezo1 and Piezo2 in chondrocytes protects against post-traumatic osteoarthritis structural damage and pain in mice.

The paper identifies a NOTCH3 variant, p.Arg1231Cys, enriched in South Asians and strongly associated with stroke risk, highlighting the importance of genetic diversity in stroke research.

This study investigates how TRPV4 mutations affect chondrocyte differentiation and identifies altered BMP signaling as a mechanism for skeletal dysplasia.

The paper identifies rare coding variants in CHRNB2 associated with reduced smoking likelihood and links them to downstream smoking-related phenotypes.

This paper develops a synthetic mechanogenetic gene circuit in engineered tissues that produces a therapeutic drug in response to mechanical loading.

This study identifies a feedforward mechanism in osteoarthritis where IL-1-induced Piezo1 upregulation enhances mechanotransduction and contributes to cartilage damage.

The paper identifies kenpaullone as a compound that enhances KCC2 expression and reduces pathologic pain by restoring inhibitory neurotransmission in mouse models.