Author

Yong Chen

Duke Medical CenterORCID 0000-0001-8824-7187Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Yong Chen7 papers · Anhui Medical University

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Wolfgang LiedtkeiD· 2 shared Alireza SavadipouriD· 1 shared Amy L. McNultyiD· 1 shared Andrey V. BortsoviD· 1 shared Changyu JiangiD· 1 shared Fang LiuiD· 1 shared Farshid GuilakiD· 1 shared Gang CheniD· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Wolfgang LiedtkeORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintMay 23, 2020

Osteoarthritis: articular chondrocyte inflammatory signaling leads to enhanced gene expression and function of mechanotransduction channel Piezo1 as a pathogenic feedforwardmechanism

Whasil Lee, Robert J. Nims, Alireza Savadipour…·Wolfgang Liedtke

This study identifies a feedforward mechanism in osteoarthritis where IL-1-induced Piezo1 upregulation enhances mechanotransduction and contributes to cartilage damage.

1 citation

humanbulk RNA-seq

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NeurosciencebioRxivPreprintMar 19, 2020

Repurposing cell growth-regulating compounds identifies kenpaullone which ameliorates pathologic pain via normalization of inhibitory neurotransmission

Michele Yeo, Yong Chen, Changyu Jiang…·Wolfgang Liedtke

The paper identifies kenpaullone as a compound that enhances KCC2 expression and reduces pathologic pain by restoring inhibitory neurotransmission in mouse models.

DOI 10.1101/767681

mouseexperimental assay

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