Transient ATR inhibition following ionizing radiation enhances immune-mediated antitumor response and survival
Joshua J. Deppas, Brian F. Kiesel, Frank P. Vendetti, Pinakin Pandya, Jianxia Guo, Kristine L. Cooper, Matthew J Bakkenist, Meysam Tavakoli, Maria Stefania diMayorca, Naveed M. Islam, David A Clump, Christopher J. Bakkenist, Jan Hendrik Beumer
The paper shows that transient ATR inhibition with ceralasertib and elimusertib, but not berzosertib, enhances antitumor immune responses and survival when combined with ionizing radiation in a mouse model.
bioRxiv · May 28, 2026 · PreprintCancer Biology