Jan Hendrik Beumer

The paper shows that transient ATR inhibition with ceralasertib and elimusertib, but not berzosertib, enhances antitumor immune responses and survival when combined with ionizing radiation in a mouse model.

This study shows ATR kinase inhibitors cause mitochondrial fission and impair immune memory in CD8+ T cells during viral infection.

This study shows that all-trans retinoic acid (ATRA) improves immune response in IDH-mutant gliomas by restoring the RA pathway, leading to tumor regression in mouse models and a clinical trial for human patients.

The paper shows that dU-rich cytoplasmic DNA inhibits STING-dependent immune responses and enhances anti-PD-L1 therapy efficacy in tumors.

Maternal administration of mitochondrial-targeted JP4-039 mitigates fetal brain injury and preserves mitochondrial function after mid-gestation radiation exposure.